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Mascharak Lab Publications

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Most Recent Publications

Dalton CMat Inorg

S. J. Carrington, I. Chakraborty, J. Bernard and P. K. Mascharak, A Theranostic Two-tone Luminescent photoCORM Derived from Rhenium and (2-pyridyl)benzothiazole: Trackable CO Delivery to Malignant Cells. Inorg. Chem. DOI 10.1021/acs.inorgchem.6b00511. PMID: 27082125
Highlighted on the cover of the journal, August 15, vol. 55, 2016.

F. P. Rodrigues, Z. A. Carneiro, P. K. Mascharak, C. Curti and R. S. da Silva, Incorporation of a Ruthenium Nitrosyl Complex into Liposomes, the Nitric Oxide Released from these Liposomes and HepG2 Cell Death Mechanism. Coord. Chem. Rev. 2016, 306, 701-707. PMID: Not Available

I. Chakraborty, S. J. Carrington, J. Hauser, S. R. J. Oliver and P. K. Mascharak, Rapid Eradication of Human Breast Cancer Cells through Trackable Light-triggered CO Delivery by Mesoporous Silica Nanoparticles Packed with a Designed photoCORM. ACS Chem. Mater. 2015, 27, 8387-8397. PMID: Not Available
Highlighted on the cover of the journal, December 22, vol. 27, 2015.

J. Jiminez, I. Chakraborty and P. K. Mascharak, Syntheses and Structures of Ruthenium(II) Di- and Tri-carbonyl Complexes Derived from 4,5-diazafluoren-9-one. Acta Cryst. Sec. C, 2015, C71, 965-968. PMID: 26524168

J. Jimenez, I. Chakraborty and P. K. Mascharak, Synthesis and Assessment of CO Release Capacity of Manganese Carbonyl Complexes Derived from Rigid α-Diimine Ligands of Varied Complexity. Eur. J. Inorg. Chem. 2015, 5021-5026. PMID: Not Available

T. R. deBoer, I. Chakraborty and P. K. Mascharak, Design and Construction of a Silver(I)-loaded Cellulose-based Wound Dressing: Trackable and Sustained Release of Silver for Controlled Therapeutic Delivery to Wound Sites. J. Mat. Sci: Med. Sci. 2015, 26:243. PMID: 26411439

S. J. Carrington, I. Chakraborty and P. K. Mascharak, Exceptionally Rapid CO Release from a Manganese(I) Tricarbonyl Complex Derived from bis(4-chlorophenylimino)acenaphthene upon Exposure to Visible Light. Dalton Trans. 2015, 44, 13828-13834. PMID: 25952559
Highlighted on the cover of the journal, August 21, vol. 44, 2015.
Highlighted in “Hot Articles of 2015”, Dalton Transactions

S. J. Carrington, I. Chakraborty, J. Bernard and P. K. Mascharak, Synthesis and Characterization of a “Turn-on” photoCORM for Trackable CO Delivery to Biological targets. ACS Med. Chem. Lett. 2014, 5, 1324-1328. PMID: 25516792

T. R. deBoer, I. Chakraborty, M. M. Olmstead and P. K. Mascharak, Supramolecular Assembly of Ag(I) Centers: Diverse Topologies Directed by Anionic Interactions. ACS Cryst. Growth Des. 2014, 14, 4901-4905. PMID: 25285050

I. Chakraborty, S. J. Carrington and P. K. Mascharak, Design Strategies to Improve the Sensitivity of Photoactive Metal Carbonyl Complexes (photoCORMs) to Visible Light and their Potential as CO-Donors to Biological Targets. Acc. Chem. Res. 2014, 47, 2603- 2611. PMID: 25003608

I. Chakraborty, S. J. Carrington and P. K. Mascharak, Photodelivery of CO by Designed photoCORMs: Correlation Between Absorption in the Visible Region and Metal-CO Bond Labilization in Carbonyl Complexes. Invited article, Special Issue of ChemMedChem on “Metals in Medicine”, 2014, 9, 1266-1274. PMID: 24756950

T. R. deBoer-Maggard, R. I. Palomino, S. O. Idiga, G. L. Millhauser and P. K. Mascharak, Nitration of Tyrosine by Peroxynitrite Generated In Situ in a Light- Controlled Platform: Effects of pH and Thiols. J. Inorg. Biochem. 2014, 138, 24-30. PMID: 24857804

M. A. Gonzalez, H. Han, A. Moyes, A. Radinos, A. J. Hobbs, N. Coombs, S. R. J. Oliver and P. K. Mascharak, Light-Triggered Carbon Monoxide Delivery with Al-MCM-41- based Nanoparticles Bearing a Designed Manganese Carbonyl Complex. J. Mater. Chem. B. 2014, 2, 2107-2113. PMID: Not Available

M. A. Gonzalez and P. K. Mascharak, Photoactive Metal Carbonyl Complexes as Potential Agents for Targeted CO Delivery. Invited Review in Special Issue of J. Inorg. Biochem. On “Gas and Redox Sensing”, 2014, 133, 127-135. PMID: 24287103

S. Sen, B. Kawahara, N. L. Fry, D. Zhang, P. K. Mascharak and G. Chaudhuri, A Light-Activated NO Donor Attenuates Colony Forming Potential of Cancer cells: Important Role of a Cross Talk Between NO and other Reactive Oxygen Species. Archiv. Biochem. Biophys. 2013, 540, 33-40. PMID: 24157690

S. J. Carrington, I. Chakraborty and P. K. Mascharak, Rapid CO Release from a Mn(I) Carbonyl Complex Derived from azopyridine upon Exposure to Visible Light and its Phototoxicity Toward Malignant Cells. Chem. Commun. 2013, 49, 11254-11256. PMID: 24081428
Highlighted on the cover of the journal, December 14, vol. 49, 2013.

T. deBoer-Maggard, A. Resendez and P. K. Mascharak, Construction of a Biomimetic Peroxynitrite -Generating Platform: A Two-component System to Synthesize Peroxynitrite in Situ Under the Control of Light. ChemBioChem, 2013, 14, 2106-2109. PMID: 24105899

M. A. Gonzalez, S. J. Carrington, I. Chakraborty, M. M. Olmstead and P. K. Mascharak, Photoactivity of Mono- and Di-Carbonyl Complexes of Ru(II) Bearing an N,N,S-Donor Ligand: Role of Ancillary Ligands on the Capacity of CO Photorelease. Inorg. Chem. 2013, 52, 11320-11331. PMID: 24067067

S. J. Carrington, I. Chakraborty and P. K. Mascharak, Differences in the CO Photolability of cis- and trans-[RuCl2(azpy)(CO)2] Complexes: Effect of Metal-to-Ligand Back Bonding. Inorg. Chim. Acta, 2013, 407, 121-125. PMID: 24273336

T. deBoer-Maggard, N. L. Fry and P. K. Mascharak, Evidence of Dexter Energy Transfer in NO Photolability of Dye-sensitized Ruthenium Nitrosyls. Inorg. Chim. Acta, 2013, 406, 190-195. PMID: Not Available

B. J. Heilman and P. K. Mascharak, Light-triggered NO Delivery to Malignant Sites and Infection. Phil. Trans. R. Soc. 2013, 371, doi:10.1098/rsta.2012.0368. PMID: 23776301

B. J. Heilman, A. C. Tadle, L. R. Pimentel and P. K. Mascharak, Selective Damage to Hyphal Form Through Light-induced Delivery of Nitric Oxide to Candida Albicans. J. Inorg. Biochem. 2013, 123, 18-22. PMID: 23501134

M. A. Gonzalez, S. J. Carrington, N. L. Fry, J. L. Martinez and P. K. Mascharak, Syntheses, Structures and Properties of New Manganese Carbonyls as Photoactive CO-releasing Molecules (photoCORMs): Design Strategies that Lead to CO Photolability in the Visible Region. Inorg. Chem. 2012, 51, 11930-11940. PMID: 23088740

G. M. Halpenny, B. J. Heilman and P. K. Mascharak, Nitric Oxide (NO)-Induced Death of Gram-negative Bacteria from a Light Controlled NO-Releasing Platform. Chemistry Biodiversity, 2012, 9, 1829-1839. PMID: 22976973

B. J. Heilman, J. St. John, S. R. J. Oliver and P. K. Mascharak, Light-triggered Eradication of Acinetobacter baumannii by means of NO Delivery from a Porous Material with an Entrapped Metal Nitrosyl. J. Am. Chem. Soc. 2012, 134, 11573-11582. PMID: 22578172
Highlighted in Chemical and Engineering News Science Section, June 11, 2012, p.37
Highlighted on the cover of the journal, July 18, vol 134, 2012 and included in the Spotlight Section

N. L. Fry and P. K. Mascharak, Photolability of NO in Designed Metal Nitrosyls with Carboxamido-N Donors: A Theoretical Attempt to Unravel the Mechanism. (Invited Perspective Article) Dalton Transactions, 2012, 41, 4726-4735. PMID: 22388493

M. A. Gonzalez, M. A. Lim, S. Cheng, A. Moyes, A. J. Hobbs and P. K. Mascharak, Manganese Carbonyls Bearing Tripodal Polypyridine Ligands as Photoactive Carbon Monoxide Releasing Molecules (photoCORMs). Inorganic Chemistry, 2012, 51, 601-608. PMID: 22148670

P. K. Mascharak, NO- and CO-donors: An Emerging Class of Pharmaceuticals in Current Medicine, (Invited Thematic Review) Ind. J. Chem. A, 50th Anniversary Issue, 2012, 51A, 99- 107.

A. C. Merkle, N. L. Fry, P. K. Mascharak and N. Lehnert, The Mechanism of NO Photodissociation in Photolabile Mn-NO Complexes with Pentadentate N5 Ligands. Inorg. Chem. 2011, 50, 12192-12203. PMID: 22040173

B. J. Heilman, G. M. Halpenny and P. K. Mascharak, Synthesis, Characterization, and Light- controlled Antibiotic Application of a Composite Material Derived from Polyurethane and Silica Xerogel with Embedded Photoactive Manganese Nitrosyl. J. Biomed. Mat. Res: Part B, 2011, 99B(2), 328-337. PMID: 21948317

ACS Chemcomm JACS

M. M. Olmstead, A. A. Eroy-Reveles and P. K. Mascharak, [Mn(bpb)(DMAP)(NO)], a {Mn- NO}6 nitrosyl with Z = 8. Acta Cryst. Sect. E, 2011, E67, m1451-m1452. PMID: 22058717

N. L. Fry, J. Wei and P. K. Mascharak, Triggered Dye Release via Photodissociation of Nitric Oxide from Designed Ruthenium Nitrosyls: Turn-ON Fluorescence Signaling of Nitric Oxide Delivery. Inorg. Chem. 2011, 50, 9045-9052. PMID: 21815610

N. L. Fry and P. K. Mascharak, Photoactive Ruthenium Nitrosyls as NO Donors: How to Sensitize them Toward Visible Light. Acc. Chem. Res. 2011, 44, 289-298. PMID: 21361269
Highlighted on the cover of the journal.

M. A. Gonzalez, N. L. Fry, R. Burt, R. Davda, A. Hobbs and P. K. Mascharak, Designed Metal Carbonyls as Carbon Monoxide (CO) Releasing Molecules (CORMs): Rapid CO Release and Delivery to Myoglobin in Aqueous Buffer, and Vasorelaxation of Mouse Aorta. Inorg. Chem. 2011, 50, 3127-3134. PMID: 21384844

N. L. Fry, X. P. Zhao and P. K. Mascharak, Density Functional Theory Studies on a Designed Photoactive {FeNO}6 Nitrosyl and the Corresponding Photoinactive {FeNO}7 Species: Insight into the Origin of NO Photolability. Inorg. Chim. Acta 2011, 367, 194-198.

N. L. Fry, B. J. Heilman and P. K. Mascharak, Dye-tethered Ruthenium Nitrosyls Containing Planar Dicaboxamide Tetradentate Ligands: Effects of In-Plane Ligand Twist on NO Photolability. Inorg. Chem. 2011, 50, 317-324. PMID: 21114262

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